| Grignard | S-CBS Reagent |
| Chiral Reduction | S-CBS Reagent |
| Chemical Resolution | (+) CSA, L (+) Tartaric acid |
Biotransformations
| Enzyme mediated resolution using Hydrolases D
|
Organometallic
| RMgX |
| Organoborane Chemistry | Boran, DMS |
| Palladium Chemistry (take from Sheikh) | Pd reagents, Phospho Ligands |
Cyanation
| NaCN
|
Chlorination
| POCl3, HCl |
Bromination
| Bromine/ HBr in Acetic acid, NBS, DBH |
Nitration
| HNO3/ H2SO4 |
Reductive Amination
| Hydrazine Hydrate, Pd/C |
Catalytic Hydrogenation
| H2, Raney Nickel, Pd/C
|
Reduction
| NaBH4, LiAlH4, L-selectride |
Condensation
| Potassium amide |
Cyclization
| Acylating reagent/AlCl3 |
Friedel Crafts
| AlCl3
|
Wittig
| Methyltriphenylphosphonium Bromide |
| Mesylation/Tosylation | Methanesulfonyl Chloride- Tosyl Sulfonylchloride |
Methylation
| MeI/KOH, Dimethyl sulphate/KOH |
| Demethylation | N-Demethylation using Sodium acetate/I2 |
| Dehydrogenation | DDQ, N,O-Bis(trimethylsilyl)trifluoroacetamide (BSTFA) in Toluene |
Gewald Reaction
| EDCI / HOBT
|
